Understanding how cells decide to die
Official title: Systems and Network-level Regulation of Cell Death
Funded at Univ of Massachusetts Med Sch Worcester · NIH-11134562 · Data updated 2026-11-12
This study is looking at how cells decide to die when they're under stress, which is important for understanding cancer, and it hopes to find new ways to improve treatments for patients.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of Massachusetts Med Sch Worcester NIH-funded |
| Lab location | 1 site (Worcester, United States) |
| Project start | July 10, 2024 |
| Project end | April 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $418,750 |
| NIH project number | 5R35GM152194-02 |
| Project ID | NIH-11134562 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients with cancers that may be influenced by the mechanisms of regulated cell death.
✕Less likely to help
Patients with non-cancerous conditions or those whose diseases do not involve regulated cell death mechanisms may not benefit from this research.
What this research studies
This research investigates the mechanisms that control regulated cell death, focusing on various forms of cell death such as apoptosis and regulated necrosis. The team aims to uncover how cells sense stress and make decisions about their own death, which is crucial for understanding diseases like cancer. By studying the interactions between different cell death pathways, the research seeks to identify potential therapeutic targets that could improve treatment outcomes. Patients may benefit from insights that could lead to more effective cancer therapies.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance the effectiveness of cancer therapies by manipulating cell death pathways.
How similar studies have gone: Other research has shown promise in understanding cell death mechanisms, suggesting that this approach could lead to significant advancements in cancer treatment.
Where this research is happening
-
Univ of Massachusetts Med Sch Worcester
Worcester, United States Active
Researchers
- Principal investigator: Lee, Michael Jungho — Univ of Massachusetts Med Sch Worcester
- Study coordinator: Lee, Michael Jungho
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.