Understanding how cells control their size during division
Official title: Mechanisms of cell size determination by the mitotic cyclin Cdc13
Funded at Dartmouth College · NIH-11070566 · Data updated 2026-11-12
This study is looking at how a type of yeast controls its size and division based on the nutrients it gets, which could help us understand more about diseases that involve cell growth.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Dartmouth College NIH-funded |
| Lab location | 1 site (Hanover, United States) |
| Project start | January 1, 2025 |
| Project end | June 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $48,974 |
| NIH project number | 1F31GM156081-01A1 |
| Project ID | NIH-11070566 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions related to abnormal cell growth or division, such as certain types of cancer.
✕Less likely to help
Patients with conditions unrelated to cell size regulation or those not experiencing issues with cell growth and division may not benefit from this research.
What this research studies
This research investigates the mechanisms by which eukaryotic cells, specifically fission yeast, regulate their size to ensure proper cell function and division. The study focuses on the role of the cyclin Cdc13 and its interaction with the cyclin-dependent kinase Cdk1, particularly how nutrient availability affects their activity and the timing of cell division. By using advanced genetic tools, the research aims to uncover how cells monitor their growth and respond to environmental conditions, which could have implications for understanding diseases related to cell size regulation.
Why it matters
Potential benefit: If successful, this research could lead to new insights into how cell size control mechanisms function, potentially informing treatments for diseases such as cancer where cell division is dysregulated.
How similar studies have gone: Previous research has shown success in understanding cell cycle regulation in model organisms, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Dartmouth College
Hanover, United States Active
Researchers
- Principal investigator: Vandal, Sarah E. — Dartmouth College
- Study coordinator: Vandal, Sarah E.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.