Understanding how cells control DNA replication and repair
Official title: Elucidating mechanisms underlying replication checkpoint control
Funded at University of Tx Md Anderson Can Ctr · NIH-11085297 · Data updated 2026-11-12
This study looks at how certain proteins help cells fix their DNA when it's damaged, which is especially important for cancer treatment, and aims to find better ways to use these proteins to improve therapy for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Tx Md Anderson Can Ctr NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | June 16, 2023 |
| Project end | May 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $499,417 |
| NIH project number | 5R01CA278758-03 |
| Project ID | NIH-11085297 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients undergoing treatment for cancer who may benefit from therapies that involve replication checkpoint inhibitors.
✕Less likely to help
Patients with cancers that do not involve replication stress or those who are not receiving treatment involving checkpoint inhibitors may not benefit from this research.
What this research studies
This research investigates the mechanisms that help cells maintain their genetic integrity when faced with DNA damage or stress during replication. It focuses on two key proteins, ATR and CHK1, which play crucial roles in coordinating DNA repair and cell cycle checkpoints. By studying how these proteins function and interact with other cellular components, the research aims to develop better strategies for using replication checkpoint inhibitors in cancer therapy, potentially improving treatment outcomes for patients. The findings could lead to advancements in the use of these inhibitors in clinical settings.
Why it matters
Potential benefit: If successful, this research could enhance cancer treatment by improving the effectiveness of therapies that target DNA replication checkpoints.
How similar studies have gone: Previous research has shown promise in using replication checkpoint inhibitors in cancer therapy, indicating that this approach has potential for success.
Where this research is happening
-
University of Tx Md Anderson Can Ctr
Houston, United States Active
Researchers
- Principal investigator: Chen, Junjie — University of Tx Md Anderson Can Ctr
- Study coordinator: Chen, Junjie
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.