Germline clues to skin-related immune side effects from cancer immunotherapy
Official title: Discovering and characterizing the germline mechanisms of cutaneous immune-related adverse events (cirAE)
Funded at University of Tx Md Anderson Can Ctr · NIH-11606584 · Data updated 2026-11-12
This grant looks for genetic clues in people treated with immune checkpoint inhibitors to understand why some develop skin-related immune side effects.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Tx Md Anderson Can Ctr NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | September 22, 2026 |
| Project end | August 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $669,309 |
| NIH project number | 7R01AR085629-02 |
| Project ID | NIH-11606584 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with cancer who are receiving or have received immune checkpoint inhibitor therapy and have or are at risk for cutaneous irAEs.
✕Less likely to help
Patients without irAEs or not treated with ICIs may not directly benefit.
What this research studies
Researchers will analyze germline DNA from thousands of cancer patients who received immune checkpoint inhibitors to find genetic variants linked to cutaneous immune-related adverse events. They will combine these genetic findings with spatial and longitudinal molecular data to map when and how these skin reactions occur. The project also aims to identify the exact genes and biological pathways causing cirAEs and to see how these variants might influence anti-tumor responses and survival. A prospective molecular phenotyping effort will trace the mechanisms of cirAE risk over time and in different body contexts.
Why it matters
Potential benefit: Better prediction and understanding of who is at risk for skin-related side effects from immunotherapy, potentially leading to safer, more personalized cancer treatment.
How similar studies have gone: This area is exploratory with limited prior germline studies on cirAEs, making findings potentially novel.
Where this research is happening
-
University of Tx Md Anderson Can Ctr
Houston, United States Active
Researchers
- Principal investigator: Leboeuf, Nicole R — University of Tx Md Anderson Can Ctr
- Study coordinator: Leboeuf, Nicole R
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.