Understanding how cells communicate using tiny packages
New insights into extracellular signal transduction
['FUNDING_R01'] · UNIVERSITY OF NOTRE DAME · NIH-11145899
This research explores how cells send messages to each other using tiny packages called extracellular vesicles, which could help us understand and fight bacterial infections.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF NOTRE DAME (nih funded) |
| Locations | 1 site (NOTRE DAME, UNITED STATES) |
| Trial ID | NIH-11145899 on ClinicalTrials.gov |
What this research studies
Our cells constantly communicate with each other and their surroundings, not just through direct contact or soluble factors, but also by releasing tiny sacs called extracellular vesicles (EVs). These EVs carry proteins, fats, and genetic material, allowing cells to exchange important information. This project aims to uncover new details about how these EVs are formed and how they deliver their messages. By understanding these fundamental processes, we hope to shed light on their role in various health conditions, including bacterial infections.
Who could benefit from this research
Good fit: This foundational research does not directly involve patients, but its findings could eventually benefit individuals affected by bacterial infections.
Not a fit: Patients not affected by bacterial infections or related cellular communication issues may not directly benefit from this specific line of basic research.
Why it matters
Potential benefit: If successful, this work could lead to new ways to diagnose or treat bacterial infections by targeting how cells communicate.
How similar studies have performed: The field of extracellular vesicle biology is rapidly growing with many publications, but several basic questions about their function remain to be fully understood.
Where this research is happening
NOTRE DAME, UNITED STATES
- UNIVERSITY OF NOTRE DAME — NOTRE DAME, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: D'SOUZA-SCHOREY, CRISLYN — UNIVERSITY OF NOTRE DAME
- Study coordinator: D'SOUZA-SCHOREY, CRISLYN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Bacterial Infections