Understanding how cells change shape during tissue development
Official title: Control of cell ratcheting engagement during epithelial morphogenesis
Funded at University of Denver (Colorado Seminary) · NIH-10994587 · Data updated 2026-11-12
This study looks at how cells in tissues change shape during development, focusing on the signals and structures that help them move and work together, using fruit fly embryos as a model to understand these important processes.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Denver (Colorado Seminary) NIH-funded |
| Lab location | 1 site (Denver, United States) |
| Project start | January 1, 2022 |
| Project end | December 31, 2025 |
| Funding year | 2025 |
| Award (this year) | $265,419 |
| NIH project number | 5R01GM141243-04 |
| Project ID | NIH-10994587 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research would be adults interested in the cellular mechanisms of tissue development and related disorders.
✕Less likely to help
Patients with conditions unrelated to epithelial tissue development or those under 21 years old may not receive benefit from this research.
What this research studies
This research investigates the mechanisms by which cells in epithelial tissues generate forces that lead to changes in their shape during development. It focuses on the role of specific cellular signals and structures, particularly phosphatidylinositol phosphates (PIPs), in coordinating these force-generating processes. By studying these interactions, the research aims to uncover how cells can effectively manage their shape and movement, which is crucial for proper tissue formation. The approach includes examining the dynamics of cellular structures in model organisms, such as the early Drosophila embryo.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of tissue development and potentially inform treatments for conditions related to abnormal cell behavior.
How similar studies have gone: Previous research has shown promising results in understanding cellular dynamics and morphogenesis, indicating that this approach has potential for success.
Where this research is happening
-
University of Denver (Colorado Seminary)
Denver, United States Active
Researchers
- Principal investigator: Blankenship, James Todd — University of Denver (Colorado Seminary)
- Study coordinator: Blankenship, James Todd
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.