Lysosome remodeling in cells under stress, from yeast to human health
Official title: Molecular mechanisms of lysosome remodeling in response to cellular stress
Funded at University of Denver (Colorado Seminary) · NIH-11396323 · Data updated 2026-11-12
This grant explores how lysosome membranes change when cells are stressed, with potential implications for diseases like cancer and neurodegeneration.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Denver (Colorado Seminary) NIH-funded |
| Lab location | 1 site (Denver, United States) |
| Project start | September 1, 2025 |
| Project end | August 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $407,562 |
| NIH project number | 5R35GM159962-02 |
| Project ID | NIH-11396323 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients with lysosome storage diseases or diseases linked to lysosome dysfunction, including neurodegenerative and cardiovascular conditions, may benefit from future applications of this work.
✕Less likely to help
If your condition is not linked to lysosome biology or cellular stress responses, direct benefits may be limited.
What this research studies
Researchers will study how lysosome membranes are remodeled in response to stress using budding yeast as a model. They will map the pathways that control degradation of lysosome membrane proteins and examine how transcriptional changes drive remodeling. The project aims to uncover the cellular rules that keep lysosomes functioning properly, which could illuminate why lysosome-related diseases occur. Findings could point toward new approaches to treat conditions where cellular waste processing goes awry.
Why it matters
Potential benefit: Better understanding of lysosome remodeling could lead to new strategies for treating lysosome-related diseases and age-related degenerative conditions.
How similar studies have gone: Prior research shows lysosome function affects multiple diseases, supporting the potential relevance of this remodeling work.
Where this research is happening
-
University of Denver (Colorado Seminary)
Denver, United States Active
Researchers
- Principal investigator: Yang, Xi — University of Denver (Colorado Seminary)
- Study coordinator: Yang, Xi
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.