Understanding how cells adapt their metabolism to survive stress
Official title: Mechanisms of Metabolic Adaptation: from Single Molecules to Systems Biology
Funded at University of Kansas Lawrence · NIH-11018713 · Data updated 2026-11-12
This study is looking at how our cells change their energy use when they face challenges like not getting enough nutrients or being exposed to harmful chemicals, and it aims to help us understand these changes better so we can improve treatments for chronic diseases.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Kansas Lawrence NIH-funded |
| Lab location | 1 site (Lawrence, United States) |
| Project start | January 1, 2025 |
| Project end | December 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $316,368 |
| NIH project number | 1R35GM156876-01 |
| Project ID | NIH-11018713 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with chronic diseases that may be influenced by metabolic processes.
✕Less likely to help
Patients with acute conditions unrelated to metabolic adaptation may not receive benefit from this research.
What this research studies
This research investigates the mechanisms by which cells adjust their metabolism in response to environmental stressors, such as nutrient scarcity and chemical exposure. By utilizing advanced genomics and imaging techniques, the study aims to uncover how specific metabolic pathways, like autophagy and cytochrome P450, are activated during these adaptations. The goal is to fill the knowledge gap regarding cellular responses to stress, which could lead to more effective treatments for chronic diseases. Patients may benefit from insights gained into how metabolic adaptation can influence disease progression and treatment efficacy.
Why it matters
Potential benefit: If successful, this research could lead to more targeted and effective treatments for various chronic diseases by enhancing our understanding of metabolic adaptation.
How similar studies have gone: Other research has shown success in understanding metabolic pathways in response to stress, but this approach aims to provide novel insights into the complexities of metabolic adaptation.
Where this research is happening
-
University of Kansas Lawrence
Lawrence, United States Active
Researchers
- Principal investigator: Barnaba, Carlo — University of Kansas Lawrence
- Study coordinator: Barnaba, Carlo
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.