Understanding how cell structures organize themselves in a lab-made environment
Official title: Investigating the mechanism of self-organized cortical patterning in an artificial cortex
Funded at Dartmouth College · NIH-10912068 · Data updated 2026-11-12
This study is looking at how the outer layer of cells, which helps them keep their shape and divide, organizes itself, using a special lab-made model to better understand the signals that control these patterns, with the hope of finding new ways to treat conditions like cancer.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Dartmouth College NIH-funded |
| Lab location | 1 site (Hanover, United States) |
| Project start | August 22, 2023 |
| Project end | July 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $248,873 |
| NIH project number | 5R00GM147826-04 |
| Project ID | NIH-10912068 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions related to cell division abnormalities, such as certain cancers.
✕Less likely to help
Patients with stable, non-cancerous conditions or those not affected by cell division issues may not benefit from this research.
What this research studies
This research investigates how the cell cortex, which is crucial for cell shape and division, organizes itself through dynamic patterns. Using a novel artificial cortex created from lipid bilayers and cell extracts, the study aims to replicate and understand the biochemical signals and processes that govern these patterns. By observing how these patterns form and change, researchers hope to uncover the underlying mechanisms that could inform treatments for conditions like cancer. The approach combines advanced techniques in cell biology and synthetic biology to bridge gaps in current knowledge.
Why it matters
Potential benefit: If successful, this research could lead to new insights into cell division and potentially inform cancer treatment strategies.
How similar studies have gone: While the approach of using an artificial cortex is innovative, similar studies in cell signaling and division have shown promising results in understanding cellular processes.
Where this research is happening
-
Dartmouth College
Hanover, United States Active
Researchers
- Principal investigator: Landino, Jennifer Elaine — Dartmouth College
- Study coordinator: Landino, Jennifer Elaine
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.