Understanding how cell-free hemoglobin damages blood vessel linings during sepsis
Official title: Mechanisms of Cell-Free Hemoglobin-Mediated Injury to the Pulmonary Endothelial Glycocalyx in Sepsis
Funded at Vanderbilt University · NIH-10917107 · Data updated 2026-11-12
This study is looking at how a substance called cell-free hemoglobin can harm the protective layer of blood vessels in people with sepsis, with the goal of finding better ways to treat and help patients avoid serious complications like breathing problems.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University NIH-funded |
| Lab location | 1 site (Nashville, UNITED STATES) |
| Project start | September 1, 2023 |
| Project end | August 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $34,164 |
| NIH project number | 5F30HL170483-02 |
| Project ID | NIH-10917107 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with sepsis, particularly those experiencing or at risk for acute respiratory distress syndrome.
✕Less likely to help
Patients who do not have sepsis or related conditions may not receive any benefit from this research.
What this research studies
This research investigates the harmful effects of cell-free hemoglobin (CFH) on the endothelial glycocalyx, a protective layer lining blood vessels, in patients suffering from sepsis. By examining the mechanisms through which CFH contributes to increased permeability of blood vessels, the study aims to uncover the biological processes that lead to complications such as acute respiratory distress syndrome (ARDS). The research employs advanced methodologies to analyze the relationship between CFH levels and endothelial injury, which could provide insights into potential therapeutic targets for improving patient outcomes. Patients with sepsis may benefit from a better understanding of these mechanisms, leading to improved treatment strategies.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that protect blood vessel linings and reduce complications in sepsis patients.
How similar studies have gone: Previous research has shown promising results in understanding the role of endothelial injury in sepsis, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Vanderbilt University
Nashville, United States Active
Researchers
- Principal investigator: Bogart, Avery May — Vanderbilt University
- Study coordinator: Bogart, Avery May
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.