Understanding how cell death affects kidney recovery after injury
Official title: Ferroptosis and Ferroptotic Stress in Maladaptive Renal Repair
Funded at Duke University · NIH-11014073 · Data updated 2026-11-12
This study is looking into how sudden kidney damage can lead to long-term problems and why men seem to be more affected than women, with a focus on a harmful type of cell death; the goal is to find ways to help kidneys heal better and prevent future issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project start | March 15, 2023 |
| Project end | January 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $494,142 |
| NIH project number | 5R01DK133369-03 |
| Project ID | NIH-11014073 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals who have experienced acute kidney injury, particularly those at risk for chronic kidney disease.
✕Less likely to help
Patients with chronic kidney disease who have not experienced acute kidney injury may not benefit from this research.
What this research studies
This research investigates the mechanisms behind acute kidney injury (AKI) and how it leads to chronic kidney disease (CKD). It focuses on a specific type of cell death called ferroptosis, which is particularly harmful to kidney cells after injury. By using advanced techniques like single-cell transcriptomics and mouse models, the study aims to uncover why males are more severely affected by AKI compared to females and to identify potential targeted therapies to improve kidney recovery. The goal is to better understand the biological processes involved and develop strategies to prevent long-term kidney damage.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve kidney recovery and reduce the risk of chronic kidney disease in patients who experience acute kidney injury.
How similar studies have gone: Previous research has shown promising results in understanding cell death mechanisms in kidney injury, but this specific focus on ferroptosis in the context of sex differences is relatively novel.
Where this research is happening
-
Duke University
Durham, United States Active
Researchers
- Principal investigator: Souma, Tomokazu — Duke University
- Study coordinator: Souma, Tomokazu
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.