Understanding how cell communication affects tissue development and disease
Official title: Decoding cortical Notch signaling and morphogenic instruction at cell-cell interfaces
Funded at University of California, San Francisco · NIH-10891671 · Data updated 2026-11-12
This study is looking at how genes and the way cells are arranged interact with each other, especially in how cells communicate, to better understand how tissues develop and heal, which could help us learn more about certain diseases.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project start | July 20, 2023 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $403,750 |
| NIH project number | 5R35GM150987-02 |
| Project ID | NIH-10891671 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions related to tissue development or diseases influenced by cell signaling, such as certain cancers or cardiovascular diseases.
✕Less likely to help
Patients with conditions unrelated to cell signaling or tissue architecture may not benefit from this research.
What this research studies
This research investigates the complex interactions between genetic programs and the physical organization of cells, particularly at cell-cell interfaces. By focusing on the Notch signaling pathway, which plays a crucial role in cell communication, the study aims to uncover how these signals influence cell behavior and tissue architecture. Using advanced biomimetic microfluidic models, researchers will explore how changes in cell mechanics and gene expression work together to shape multicellular structures. This could provide insights into tissue development and regeneration, as well as the mechanisms underlying various diseases.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating diseases related to tissue development and regeneration.
How similar studies have gone: Previous research has shown promising results in understanding cell signaling pathways and their impact on tissue behavior, indicating that this approach has potential for success.
Where this research is happening
-
University of California, San Francisco
San Francisco, United States Active
Researchers
- Principal investigator: Kutys, Matthew L — University of California, San Francisco
- Study coordinator: Kutys, Matthew L
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.