Understanding how CD7 affects T cell function
Official title: Unmasking the Immunomodulatory Roles of CD7 Signaling
Funded at University of Utah · NIH-10891386 · Data updated 2026-11-12
This study is looking at how a protein called CD7 helps T cells, which are important for fighting infections and diseases, do their job better or worse, and it could lead to new treatments for conditions like cancer and autoimmune diseases.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Utah NIH-funded |
| Lab location | 1 site (Salt Lake City, United States) |
| Project start | July 20, 2023 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $611,046 |
| NIH project number | 5R01AI175301-02 |
| Project ID | NIH-10891386 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with viral infections, cancers, or autoimmune diseases who may benefit from enhanced T cell function.
✕Less likely to help
Patients with conditions unrelated to T cell function or those who do not have immune system involvement may not benefit from this research.
What this research studies
This research investigates the role of CD7 in T cells, focusing on how it influences T cell receptor signaling and overall immune responses. The study aims to uncover the mechanisms by which CD7 supports T cell differentiation during infections, cancers, and autoimmune diseases. By analyzing T cell behavior at various biological levels, the research seeks to determine how targeting CD7 could enhance or suppress T cell activity, potentially leading to new therapeutic strategies.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve immune responses in patients with infections, cancers, or autoimmune diseases.
How similar studies have gone: Previous research has shown promising results in targeting similar immunomodulatory pathways, suggesting potential for success in this novel approach.
Where this research is happening
-
University of Utah
Salt Lake City, United States Active
Researchers
- Principal investigator: Lo, Wan-Lin — University of Utah
- Study coordinator: Lo, Wan-Lin
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.