Understanding how CBM complex mutations cause atopic diseases and finding new ways to treat them
Official title: Mechanistic elucidation of pathogenic CBM complex mutations associated with atopic disease
Funded at Henry M. Jackson Fdn for the Adv Mil/med · NIH-11365762 · Data updated 2026-11-12
Researchers are studying how specific genetic changes in the CBM complex lead to eczema, asthma, and infections so future therapies can target these pathways.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Henry M. Jackson Fdn for the Adv Mil/med NIH-funded |
| Lab location | 1 site (Bethesda, United States) |
| Project start | July 5, 2023 |
| Project end | June 30, 2028 |
| Funding year | 2026 |
| Award (this year) | $676,572 |
| NIH project number | 5R01AI168295-04 |
| Project ID | NIH-11365762 on NIH RePORTER |
Who could benefit from this research
✓Could help
Individuals with atopic diseases (eczema, asthma, food allergies) who have or may have CBM complex gene mutations affecting CARD11, BCL10, or MALT1.
✕Less likely to help
Patients without CBM-related atopy or unrelated allergic diseases may not benefit from this research.
What this research studies
This project will investigate how mutations in the CBM complex (CARD11, BCL10, MALT1) disrupt immune cell signaling and cause allergic diseases. By studying patient blood cells and other samples, the team aims to map which cell signals go wrong and how B and T cells behave differently in people with atopy. They will explore whether glutamine could help correct these signaling defects and reduce allergy symptoms. The work combines genetic analysis, cellular studies, and collaboration with broader patient groups to understand how common and rare CBM-related atopy affects individuals. Results could point to personalized approaches for treating atopic diseases linked to these mutations.
Why it matters
Potential benefit: Potentially clearer targets for therapies that reduce allergic symptoms and infections in patients with CBM complex mutations.
How similar studies have gone: Prior work has linked CBM mutations to atopy and abnormal lymphocyte function, supporting further investigation.
Where this research is happening
-
Henry M. Jackson Fdn for the Adv Mil/med
Bethesda, United States Active
Researchers
- Principal investigator: Snow, Andrew L — Henry M. Jackson Fdn for the Adv Mil/med
- Study coordinator: Snow, Andrew L
Related research
Other NIH-funded projects on the same topics.
-
Cooperation partners of SETBP1 in AML development
This grant explores how SETBP1 and AF9 (MLLT3) work together to drive acute myeloid leukemia and whether targeting related epigenetic regulators could help treat aggressive CK-AML.
-
U.S. Military HIV Research Program Clinical Trials Unit expansion
A nationwide network of clinical trial sites is being expanded to test HIV prevention and treatment approaches through DAIDS-supported trials.
-
Novel protein biomarkers of chronic pain in adults using a pain registry biobank
A study in adults with chronic pain will look for new protein biomarkers in blood samples to understand better why pain persists and how to improve treatment.
-
Tailored antibody cures for HIV using AI and vaccines
A study to design personalized antibody-based strategies to achieve HIV remission, using lab experiments and computer models to tailor vaccines or antibody treatments to individuals or small groups.
-
Understanding how antibody protection works using 3D protein structures
Researchers will build a 3D-based method to see which viral features relate to prevention by antibodies, using data from people in HIV vaccine and monoclonal antibody trials.
-
Military HIV Clinical Network
This program runs HIV and TB prevention and treatment clinical studies for adults in military-associated and high-HIV-burden communities.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.