Novel protein biomarkers of chronic pain in adults using a pain registry biobank
Official title: Novel Protein Biomarkers of Chronic Pain: Cross-Sectional and Longitudinal Analyses Using the DVCIPM Pain Registry Biobank
Funded at Henry M. Jackson Fdn for the Adv Mil/med · NIH-11498721 · Data updated 2026-11-12
A study in adults with chronic pain will look for new protein biomarkers in blood samples to understand better why pain persists and how to improve treatment.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Henry M. Jackson Fdn for the Adv Mil/med NIH-funded |
| Lab location | 1 site (Bethesda, United States) |
| Project start | September 15, 2026 |
| Project end | August 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $135,741 |
| NIH project number | 1R03NS153803-01 |
| Project ID | NIH-11498721 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults 21 years and older with chronic pain who are participants in or whose data are represented in the DVCIPM Pain Registry Biobank.
✕Less likely to help
Patients not represented in the pain registry or without chronic pain may not directly benefit from this study.
What this research studies
This project will use cross-sectional and longitudinal analyses of data and biospecimens from the DVCIPM Pain Registry Biobank to identify blood-based protein markers linked to chronic pain. Researchers will examine oxidative stress, mitochondrial function, and signaling pathways related to pain and explore how these markers relate to symptoms and treatment responses over time. The study is designed to be patient-facing by leveraging a biobank of real-world samples and accompanying clinical information to guide future, non-opioid pain management approaches.
Why it matters
Potential benefit: If successful, the work could lead to better tests to personalize chronic pain treatment and reduce reliance on opioids.
How similar studies have gone: Existing research suggests that protein biomarkers can reflect pain mechanisms, but this project aims to identify novel targets in a real-world chronic pain population.
Where this research is happening
-
Henry M. Jackson Fdn for the Adv Mil/med
Bethesda, United States Active
Researchers
- Principal investigator: Rupp, Tracy Lynn — Henry M. Jackson Fdn for the Adv Mil/med
- Study coordinator: Rupp, Tracy Lynn
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.