Understanding how cancer treatment affects tumor cell behavior over time
Characterizing cytotoxic therapy induced shifts in the cost-to-benefit ratio of high ploidy
['FUNDING_R37'] · H. LEE MOFFITT CANCER CTR & RES INST · NIH-10915642
This study looks at how long-term cancer treatments affect the different types of cells in tumors, with the goal of creating more personalized and effective chemotherapy plans that work better for each patient's unique cancer.
Quick facts
| Phase | ['FUNDING_R37'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | H. LEE MOFFITT CANCER CTR & RES INST (nih funded) |
| Locations | 1 site (TAMPA, UNITED STATES) |
| Trial ID | NIH-10915642 on ClinicalTrials.gov |
What this research studies
This research investigates how cytotoxic therapies, which are designed to kill cancer cells, impact the composition of tumor cells over extended periods. It challenges traditional methods that only observe drug responses for a short duration, recognizing that cancer is often heterogeneous and may respond differently based on the genetic makeup of the tumor. By analyzing DNA content and other factors, the study aims to develop personalized treatment strategies that minimize the selection of resistant cancer cells. Patients may benefit from a more effective and tailored approach to their chemotherapy based on their tumor's unique characteristics.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with heterogeneous tumors, particularly those diagnosed with brain cancer or other types of cancers that may respond variably to cytotoxic therapies.
Not a fit: Patients with tumors that are not heterogeneous or those who are not undergoing cytotoxic therapy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective cancer treatments that better target tumor cells and reduce the chances of resistance.
How similar studies have performed: Previous research has shown promise in using personalized approaches to cancer treatment, but this specific methodology is relatively novel.
Where this research is happening
TAMPA, UNITED STATES
- H. LEE MOFFITT CANCER CTR & RES INST — TAMPA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ANDOR, NOEMI — H. LEE MOFFITT CANCER CTR & RES INST
- Study coordinator: ANDOR, NOEMI
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Brain Cancer, Cancer cell line, Cancers