Understanding how cancer cells adapt to stress and die
Cytoskeletal dynamics during uncontrolled macropinocytosis-induced cancer cell death
This study is looking at how cancer cells handle stress and what helps them survive, with the goal of finding new ways to treat cancer.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Virginia NIH-funded |
| Lab location | 1 site (Charlottesville, United States) |
| Project ID | NIH-11074874 on NIH RePORTER |
What this research studies
This research investigates how cancer cells manage stress at the cellular level, particularly focusing on the role of organelles in cancer cell death. By using advanced modeling and experiments with cancer cell cultures and primary tumors, the research aims to identify critical processes that allow cancer cells to survive and proliferate despite oncogenic stress. The project involves a collaborative effort from multiple experts in cancer biology and systems biology to explore these mechanisms and their implications for cancer treatment.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with specific types of cancer, particularly those with known oncogene activation.
Not a fit: Patients with non-cancerous conditions or those whose cancers do not involve the oncogenes being studied may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for targeting cancer cells more effectively, potentially improving treatment outcomes for patients.
How similar studies have performed: Previous research has shown promise in understanding cellular stress responses in cancer, suggesting that this approach could yield valuable insights.
Where this research is happening
Charlottesville, United States
- University of Virginia — Charlottesville, United States (Active)
Researchers
- Principal investigator: Janes, Kevin a — University of Virginia
- Study coordinator: Janes, Kevin a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.