Understanding how cancer cells adapt to stress
Systems Analysis of Stress-adapted Cancer Organelles (SASCO) Center
This study is looking at how cancer cells change their inner parts to handle stress from cancer-causing genes, with the hope of finding new ways to treat cancer by discovering their weaknesses.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Virginia NIH-funded |
| Lab location | 1 site (Charlottesville, United States) |
| Project ID | NIH-10903892 on NIH RePORTER |
What this research studies
This research investigates how cancer cells modify their internal structures, known as organelles, to cope with stress caused by oncogenes, which are genes that can lead to cancer. By combining advanced modeling techniques with experiments on cancer cell cultures and actual tumors, the project aims to identify critical pathways that allow these organelles to adapt. The goal is to uncover vulnerabilities in cancer cells that could be targeted for new treatments. A team of 14 experts in cancer biology and systems biology will collaborate on this project to explore these adaptations systematically.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with various types of cancer, particularly those with tumors influenced by oncogenes.
Not a fit: Patients with non-cancerous conditions or those whose tumors do not involve oncogene activation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies that specifically target the vulnerabilities of cancer cells, improving treatment outcomes.
How similar studies have performed: Previous research has shown promise in understanding cancer cell adaptations, but this specific approach of integrating mechanistic modeling with experimental data is relatively novel.
Where this research is happening
Charlottesville, United States
- University of Virginia — Charlottesville, United States (Active)
Researchers
- Principal investigator: Janes, Kevin a — University of Virginia
- Study coordinator: Janes, Kevin a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.