Understanding how calcium signals affect cell functions
Official title: Mechanisms of inositol trisphosphate receptor-mediated calcium signaling
Funded at University of Texas Hlth Sci Ctr Houston · NIH-11055422 · Data updated 2026-11-12
This study is looking at how certain proteins in our cells help control calcium levels, which are important for many cell functions, and it could help us understand both normal cell behavior and diseases like Alzheimer's.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Sci Ctr Houston NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | April 1, 2024 |
| Project end | January 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $464,162 |
| NIH project number | 5R35GM153178-02 |
| Project ID | NIH-11055422 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or related dementias.
✕Less likely to help
Patients with conditions unrelated to calcium signaling or those not diagnosed with neurodegenerative diseases may not benefit from this research.
What this research studies
This research investigates the molecular mechanisms behind calcium signaling in cells, particularly focusing on inositol trisphosphate receptors (IP3Rs), which are crucial for regulating various cellular functions. By studying how these receptors open and release calcium from the endoplasmic reticulum, the research aims to uncover the structural and functional aspects of calcium signaling. This could lead to insights into both healthy cellular processes and pathological conditions, such as Alzheimer's disease. The approach involves detailed structural studies and functional analyses to better understand how these channels operate.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for conditions like Alzheimer's disease by targeting calcium signaling pathways.
How similar studies have gone: Previous research has shown promising results in understanding calcium signaling mechanisms, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Texas Hlth Sci Ctr Houston
Houston, United States Active
Researchers
- Principal investigator: Serysheva, Irina I — University of Texas Hlth Sci Ctr Houston
- Study coordinator: Serysheva, Irina I
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.