Understanding how calcium signaling affects neutrophil function in inflammation
Membrane potential and Calcium Signaling in Neutrophil Development and Inflammation
This study is looking at how certain signals in our cells help immune cells called neutrophils get activated to fight off bacterial infections, with the goal of finding better treatments for conditions like lung injuries and infections that can happen when these cells don't work properly.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-10975371 on NIH RePORTER |
What this research studies
This research investigates the role of calcium signaling and membrane potential in the activation of neutrophils, which are crucial for fighting bacterial infections. The study aims to uncover the molecular mechanisms that regulate neutrophil activation, particularly focusing on ion channels and their signaling pathways. By understanding how these processes work, the research seeks to develop new therapeutic strategies to modify inflammatory diseases linked to neutrophil dysfunction. Patients may benefit from insights that could lead to improved treatments for conditions like acute lung injury and bacterial infections.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from acute inflammatory conditions, such as acute lung injury or severe bacterial infections.
Not a fit: Patients with chronic conditions unrelated to neutrophil function or inflammation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that enhance neutrophil function and improve outcomes for patients with inflammatory diseases.
How similar studies have performed: Previous research has shown promising results in understanding calcium signaling in immune cells, suggesting that this approach could yield valuable insights.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Clemens, Regina — Washington University
- Study coordinator: Clemens, Regina
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.