Understanding how calcium channels work in the brain
Official title: The Physiology of Store-Operated Channels in the Nervous System
Funded at Northwestern University at Chicago · NIH-11084492 · Data updated 2026-11-12
This study is looking at how calcium signals in the brain help with communication between nerve cells and how this might relate to brain diseases, so we can find new ways to help people with these conditions.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Northwestern University at Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project start | May 1, 2023 |
| Project end | April 30, 2031 |
| Funding year | 2025 |
| Award (this year) | $963,134 |
| NIH project number | 5R35NS132349-03 |
| Project ID | NIH-11084492 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with neurological conditions that may be linked to calcium signaling abnormalities.
✕Less likely to help
Patients with conditions unrelated to calcium signaling or those who do not have neurological disorders may not benefit from this research.
What this research studies
This research investigates the role of store-operated calcium entry (SOCE) in the brain, focusing on how calcium signaling affects neurotransmitter release, synaptic plasticity, and gene transcription. The study aims to uncover the mechanisms by which Orai channels, activated by calcium sensors in the endoplasmic reticulum, contribute to brain function. By exploring the physiological functions of SOCE in neurons and glial cells, the research seeks to clarify its implications for brain diseases and disorders. Patients may benefit from insights gained into how calcium signaling pathways can be targeted for therapeutic interventions.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for various brain disorders by targeting calcium signaling pathways.
How similar studies have gone: Previous research has shown that understanding calcium signaling in other cell types has led to significant advancements in treatment strategies, suggesting potential for success in this area as well.
Where this research is happening
-
Northwestern University at Chicago
Chicago, United States Active
Researchers
- Principal investigator: Prakriya, Murali — Northwestern University at Chicago
- Study coordinator: Prakriya, Murali
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.