Understanding how calcium channels work in cells
Official title: Molecular and cellular mechanisms of store-operated calcium channels
Funded at Stanford University · NIH-11066514 · Data updated 2026-11-12
This study is looking at how certain channels in our cells help control calcium signals, which are important for things like immune responses and muscle function, to better understand how these processes work and how they might be linked to different health issues.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project start | May 1, 2023 |
| Project end | April 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $554,867 |
| NIH project number | 5R35GM149305-03 |
| Project ID | NIH-11066514 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with autoimmune diseases or conditions related to calcium signaling dysfunction.
✕Less likely to help
Patients with conditions unrelated to calcium signaling or autoimmune disorders may not benefit from this research.
What this research studies
This research investigates the mechanisms by which store-operated calcium channels (SOCs) function in cells, focusing on how calcium signals are generated and regulated. It explores the interactions between proteins that control calcium entry, particularly in immune cells and muscle tissues. By examining the dynamics of junctions between the endoplasmic reticulum and the plasma membrane, the research aims to uncover how these processes influence various physiological functions and disease states. The study employs advanced molecular and cellular techniques to analyze these critical pathways.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for autoimmune diseases and other conditions linked to calcium signaling abnormalities.
How similar studies have gone: Previous research has shown promising results in understanding calcium signaling pathways, indicating that this approach could yield valuable insights.
Where this research is happening
-
Stanford University
Stanford, United States Active
Researchers
- Principal investigator: Lewis, Richard S — Stanford University
- Study coordinator: Lewis, Richard S
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.