Understanding how calcium affects heart cell function
Official title: Molecular insights into the regulation of mitochondrial calcium uptake
Funded at Stanford University · NIH-10901735 · Data updated 2026-11-12
This study is looking at how calcium helps power the energy factories in heart cells, which could lead to new ways to treat heart failure.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project start | August 15, 2024 |
| Project end | August 14, 2026 |
| Funding year | 2024 |
| Award (this year) | $48,974 |
| NIH project number | 1F31HL174083-01 |
| Project ID | NIH-10901735 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with heart disease or those at risk of developing heart failure.
✕Less likely to help
Patients with non-cardiac conditions or those without any mitochondrial dysfunction may not benefit from this research.
What this research studies
This research investigates the role of calcium uptake in mitochondria, which are crucial for heart cell energy production. By focusing on the mitochondrial calcium uniporter, the study aims to uncover the molecular mechanisms that regulate calcium signaling in heart cells. The approach includes a combination of structural, biophysical, and biochemical techniques to explore how this regulation impacts heart disease. Insights gained could lead to new therapeutic strategies for heart failure.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve heart function and reduce the burden of heart disease.
How similar studies have gone: Previous research has shown promising results in understanding mitochondrial function and calcium signaling, indicating potential for success in this area.
Where this research is happening
-
Stanford University
Stanford, United States Active
Researchers
- Principal investigator: Muir, Colin — Stanford University
- Study coordinator: Muir, Colin
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.