Understanding how c-Rel contributes to autoimmune diseases like multiple sclerosis
Transcriptional Checkpoints Of Autoimmune Encephalomyelitis
This study is looking at a protein called c-Rel to see how it affects autoimmune diseases like multiple sclerosis, and they're testing new small molecules that might help reduce these diseases by blocking c-Rel, with the hope of finding a new treatment for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-10742919 on NIH RePORTER |
What this research studies
This research investigates the role of a protein called c-Rel in autoimmune diseases, particularly multiple sclerosis (MS). By studying both human genetic data and animal models, the researchers aim to uncover how c-Rel influences the immune response that leads to these conditions. They have developed new small molecules that inhibit c-Rel's function, which have shown promise in reducing autoimmune responses in mice. The ultimate goal is to determine if targeting c-Rel can provide a new treatment option for patients with autoimmune diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with autoimmune diseases, particularly multiple sclerosis.
Not a fit: Patients with autoimmune conditions not related to c-Rel or those who do not have a diagnosis of multiple sclerosis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that effectively treat autoimmune diseases like multiple sclerosis.
How similar studies have performed: Previous research has indicated that targeting c-Rel may be effective in treating autoimmune diseases, suggesting a promising avenue for further exploration.
Where this research is happening
Philadelphia, United States
- University of Pennsylvania — Philadelphia, United States (Active)
Researchers
- Principal investigator: Jordan, Martha S — University of Pennsylvania
- Study coordinator: Jordan, Martha S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.