Understanding how breast cancer spreads and changes in the body
Tracing and targeting the epigenetic heterogeneity in breast cancer metastasis
This study is looking at how breast cancer cells change when they spread to other parts of the body, especially focusing on changes that aren't related to their genes, to help find better treatments for people with advanced breast cancer.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10914052 on NIH RePORTER |
What this research studies
This research investigates the complex changes that occur in breast cancer cells as they spread to other parts of the body, particularly focusing on non-genetic alterations. The team aims to explore how these changes affect the behavior of cancer cells and their response to treatments. By studying the interactions between cancer cells and bone-forming cells, the researchers hope to uncover new mechanisms that drive the diversity of cancer cell characteristics in metastasis. This could lead to better-targeted therapies for patients with advanced breast cancer.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with advanced breast cancer, particularly those experiencing metastasis to the bones.
Not a fit: Patients with early-stage breast cancer or those whose cancer has not metastasized may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for patients with metastatic breast cancer by targeting the unique characteristics of their cancer cells.
How similar studies have performed: Other research has shown promise in understanding cancer heterogeneity, but this specific approach focusing on epigenetic factors in breast cancer metastasis is relatively novel.
Where this research is happening
New York, United States
- Icahn School of Medicine at Mount Sinai — New York, United States (Active)
Researchers
- Principal investigator: Bado, Igor Landry — Icahn School of Medicine at Mount Sinai
- Study coordinator: Bado, Igor Landry
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.