Understanding how breast cancer cells evade the immune system
Tumor Intrinsic Regulation of Immune Evasion Pathways in Breast Cancer
This study is looking at how breast cancer cells hide from the immune system and aims to find new ways to help treatments work better by focusing on a specific protein called VISTA that these cancer cells use to escape detection.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project ID | NIH-10832645 on NIH RePORTER |
What this research studies
This research investigates the ways in which breast cancer cells can avoid detection and destruction by the immune system. By examining the interactions between tumor cells and immune cells, the study aims to uncover specific signaling pathways that contribute to immune evasion. The research will focus on a particular immune checkpoint protein, VISTA, which has been found to be expressed on breast cancer cells. Through laboratory experiments and analysis of patient samples, the goal is to identify new therapeutic strategies that could enhance the effectiveness of existing treatments.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with breast cancer, particularly those who may not be responding well to current treatments.
Not a fit: Patients with non-malignant breast conditions or those who have not been diagnosed with breast cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved therapies that enhance the immune response against breast cancer.
How similar studies have performed: Previous research has shown promise in understanding immune evasion in other cancers, suggesting that this approach could yield valuable insights for breast cancer as well.
Where this research is happening
Aurora, UNITED STATES
- University of Colorado Denver — Aurora, United States (Active)
Researchers
- Principal investigator: Rosenbaum, Sheera — University of Colorado Denver
- Study coordinator: Rosenbaum, Sheera
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.