Understanding how brain signals help improve precise limb movements
Official title: Defining the contributions of cerebello-spinal projection neurons to dexterous movement
Funded at Salk Institute for Biological Studies · NIH-11004660 · Data updated 2026-11-12
This study is looking at special brain cells that help control how we move our arms and legs, aiming to understand how they make our movements more precise, which could help improve treatments for people with movement disorders.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Salk Institute for Biological Studies NIH-funded |
| Lab location | 1 site (La Jolla, UNITED STATES) |
| Project start | January 4, 2023 |
| Project end | January 3, 2026 |
| Funding year | 2025 |
| Award (this year) | $44,052 |
| NIH project number | 5F31NS130972-03 |
| Project ID | NIH-11004660 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals experiencing coordination impairments or disorders related to cerebellar dysfunction.
✕Less likely to help
Patients with movement disorders not related to cerebellar function may not benefit from this research.
What this research studies
This research investigates the role of specific neurons in the cerebellum that send signals to the spinal cord, which may help refine and correct movements of the limbs in real-time. By studying these cerebello-spinal projection neurons, the research aims to uncover how they contribute to the accuracy of skilled movements, such as those required for dexterous tasks. The approach involves advanced techniques to observe and manipulate these neural circuits, providing insights into their function during movement. This could lead to a better understanding of coordination and potential treatments for movement disorders.
Why it matters
Potential benefit: If successful, this research could lead to improved therapies for individuals with movement disorders, enhancing their ability to perform daily tasks.
How similar studies have gone: While the specific focus on cerebello-spinal projections is novel, previous research has shown success in understanding cerebellar functions and their impact on movement.
Where this research is happening
-
Salk Institute for Biological Studies
La Jolla, United States Active
Researchers
- Principal investigator: Wilcox, Oren Fairlee — Salk Institute for Biological Studies
- Study coordinator: Wilcox, Oren Fairlee
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.