Molecular control of ROR-gamma-t in the chromatin landscape
Official title: Molecular Mechanisms of ROR-gamma-t Functional Regulation in Chromatin Environments
Funded at Salk Institute for Biological Studies · NIH-11451083 · Data updated 2026-11-12
A study to understand how the immune-regulating protein ROR-gamma-t works inside the DNA environment to influence immune responses and autoimmune diseases.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Salk Institute for Biological Studies NIH-funded |
| Lab location | 1 site (La Jolla, UNITED STATES) |
| Project start | July 16, 2026 |
| Project end | June 30, 2031 |
| Funding year | 2026 |
| Award (this year) | $927,512 |
| NIH project number | 1R01AI196844-01A1 |
| Project ID | NIH-11451083 on NIH RePORTER |
Who could benefit from this research
✓Could help
Individuals with autoimmune diseases or immune-related conditions where Th17 cells and inflammatory pathways are involved may benefit from future applications of this work.
✕Less likely to help
People without autoimmune or inflammatory conditions may not directly benefit from these mechanistic studies.
What this research studies
This project looks at how ROR-gamma-t interacts with chromatin to regulate genes in immune cells, which may reveal new ways to modulate inflammation. Researchers will study the DNA regions where ROR-gamma-t binds and how chromatin structure affects its function. The goal is to uncover mechanisms that could lead to safer, targeted therapies for autoimmune diseases and related conditions. By focusing on human-relevant immune processes, the work aims to translate basic biology into potential clinical approaches.
Why it matters
Potential benefit: If successful, the findings could pave the way for better-targeted therapies for autoimmune diseases by identifying chromatin contexts that influence ROR-gamma-t activity.
How similar studies have gone: Previous work has shown the importance of chromatin context in transcription factor function, but linking chromatin environments to ROR-gamma-t activity remains an emerging area.
Where this research is happening
-
Salk Institute for Biological Studies
La Jolla, United States Active
Researchers
- Principal investigator: Lyumkis, Dmitry — Salk Institute for Biological Studies
- Study coordinator: Lyumkis, Dmitry
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.