Understanding how brain receptors influence behavior
Mapping the functional GPCR-ome and its signaling consequences in neurons
This study is looking at how certain brain chemicals work with specific receptors in nerve cells to understand how they affect brain function and behavior, which could help us learn more about how our brains work.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-11063783 on NIH RePORTER |
What this research studies
This research investigates how neuromodulators, which are chemicals that influence brain activity, interact with G protein-coupled receptors (GPCRs) in neurons. By using advanced techniques like single-cell transcriptomics and biosensors, the study aims to identify which receptors are active in specific neurons and how they affect signaling pathways. The research will involve examining primary neuron cultures and live brain slices to understand the complex signaling mechanisms at play. This could lead to insights into how different receptors contribute to brain function and behavior.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults aged 21 and older who may have conditions related to neuromodulation or GPCR signaling.
Not a fit: Patients with conditions unrelated to neuromodulation or those under 21 years old may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of brain signaling, potentially leading to new treatments for neurological disorders.
How similar studies have performed: Other research has shown promising results in understanding GPCR signaling, indicating that this approach could yield valuable insights.
Where this research is happening
San Francisco, United States
- University of California, San Francisco — San Francisco, United States (Active)
Researchers
- Principal investigator: He, Xinyi Jenny — University of California, San Francisco
- Study coordinator: He, Xinyi Jenny
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.