Understanding how brain receptors are delivered to synapses
Investigating the synaptic trafficking of endogenous AMPARs
['FUNDING_FELLOWSHIP'] · UNIVERSITY OF COLORADO DENVER · NIH-10995322
This study is looking at how certain brain receptors that help with learning and memory get to the right spots in the brain, which could help us understand and find new treatments for conditions like autism and epilepsy.
Quick facts
| Phase | ['FUNDING_FELLOWSHIP'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF COLORADO DENVER (nih funded) |
| Locations | 1 site (Aurora, UNITED STATES) |
| Trial ID | NIH-10995322 on ClinicalTrials.gov |
What this research studies
This research investigates the mechanisms behind the delivery of AMPA-type glutamate receptors (AMPARs) to synapses in the brain, which are crucial for learning and memory. By developing a new toolkit to label and control the trafficking of these receptors, the research aims to uncover how they are transported to specific synapses under normal conditions and during synaptic changes. This could provide insights into the synaptic dysfunctions observed in conditions like autism and epilepsy, potentially leading to new therapeutic strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with autism spectrum disorder or related brain disorders.
Not a fit: Patients with conditions unrelated to synaptic dysfunction or those without a diagnosis of autism or similar disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for brain disorders associated with synaptic dysfunction, such as autism and epilepsy.
How similar studies have performed: Other research has shown promising results in understanding synaptic mechanisms, but this approach using endogenous AMPARs is relatively novel.
Where this research is happening
Aurora, UNITED STATES
- UNIVERSITY OF COLORADO DENVER — Aurora, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KAREEMO, DEAN — UNIVERSITY OF COLORADO DENVER
- Study coordinator: KAREEMO, DEAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: autism spectral disorder, autism spectrum disorder, Autistic Disorder, autistic spectrum disorder, Brain Diseases