Understanding how brain networks differ between sexes in anxiety and depression
Using person-specific networks to uncover sex differences in vulnerability to internalizing disorders
This project explores how individual brain network patterns, especially in the default mode network, might explain why anxiety and depression affect males and females differently, particularly in young people.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-11170014 on NIH RePORTER |
What this research studies
We know that conditions like anxiety and depression affect males and females differently, but we don't fully understand why. This project looks at how each person's unique brain connections, particularly in a key area called the default mode network, might play a role. Researchers will explore if these individual brain patterns develop differently in young males and females and if these differences contribute to how anxiety and depression show up. The goal is to better understand the brain's role in these conditions.
Who could benefit from this research
Good fit: This research is focused on understanding brain differences related to anxiety and depression in young people, specifically those between 12 and 20 years old.
Not a fit: Patients outside the 12-20 age range or those without internalizing disorders like anxiety or depression may not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to a better understanding of the unique brain mechanisms behind anxiety and depression in males and females, potentially guiding more personalized and effective treatments.
How similar studies have performed: While the idea of person-specific brain networks is gaining traction, this specific approach to understanding sex differences in the default mode network's development and its link to internalizing symptoms is a novel area of exploration.
Where this research is happening
Philadelphia, United States
- University of Pennsylvania — Philadelphia, United States (Active)
Researchers
- Principal investigator: Shanmugan, Sheila — University of Pennsylvania
- Study coordinator: Shanmugan, Sheila
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.