Understanding how brain injuries affect learning and depression.

MRI Markers of Feedback Timing during Learning in Individuals with TBI with and without Clinical Depression

NIH-funded research Kessler Foundation, INC. · NIH-11031295

This study is looking at how a traumatic brain injury affects learning in people who also have depression, and it uses brain scans to see how their brains respond to immediate versus delayed feedback during learning tasks, with the goal of finding better ways to help them recover.

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionKessler Foundation, INC. NIH-funded
Lab location1 site (East Hanover, UNITED STATES)
Project IDNIH-11031295 on NIH RePORTER

What this research studies

This research investigates how traumatic brain injury (TBI) influences learning processes in individuals, particularly focusing on those who also experience clinical depression. By using MRI technology, the study aims to identify the brain mechanisms involved in learning when feedback is provided immediately versus after a delay. The findings could lead to improved rehabilitation strategies tailored to the unique needs of TBI patients, especially those with depressive symptoms. Participants will undergo assessments to understand how their brain responds to feedback during learning tasks.

Who could benefit from this research

Good fit: Ideal candidates for this research are individuals who have experienced a traumatic brain injury and may also be dealing with clinical depression.

Not a fit: Patients who do not have a history of traumatic brain injury or clinical depression may not benefit from this research.

Why it matters

Potential benefit: If successful, this research could lead to more effective rehabilitation strategies for individuals with TBI and depression, enhancing their learning and recovery.

How similar studies have performed: Previous research has shown that understanding brain mechanisms in similar populations can lead to significant advancements in rehabilitation techniques.

Where this research is happening

East Hanover, UNITED STATES

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions Acquired brain injury
Last reviewed 2026-06-09 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.