Understanding how brain immune cells interact with neurons
How microglia sense and regulate neuronal activity in the adult brain
This study is looking at how brain immune cells called microglia react to different levels of brain activity, like during seizures or when you're under anesthesia, to help us understand more about brain function and conditions like epilepsy.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Sci Ctr Houston NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-11144614 on NIH RePORTER |
What this research studies
This research investigates the role of microglia, the immune cells in the brain, in sensing and responding to neuronal activity. It aims to uncover how these cells react during periods of heightened activity, like seizures, and reduced activity, such as during anesthesia. By using advanced imaging techniques and genetic tools, the study will explore the signaling pathways that microglia use to communicate with neurons, which could lead to new insights into brain function and disorders. Patients may benefit from a better understanding of how brain immune responses can influence conditions like epilepsy.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults experiencing neurological conditions such as epilepsy or those undergoing anesthesia.
Not a fit: Patients with stable neurological conditions who do not experience seizures or require anesthesia may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for neurological conditions by targeting microglial responses.
How similar studies have performed: Other research has shown promising results in understanding microglial functions, indicating that this approach has potential for significant findings.
Where this research is happening
Houston, United States
- University of Texas Hlth Sci Ctr Houston — Houston, United States (Active)
Researchers
- Principal investigator: Wu, Long-Jun — University of Texas Hlth Sci Ctr Houston
- Study coordinator: Wu, Long-Jun
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.