Understanding how brain circuits support short-term memory
Microcircuit mechanisms behind the distributed cortical contributions to working memory
This study is looking at how different parts of the brain help us remember things for a short time, using a fun virtual reality game for mice to see how their brains work during memory tasks.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Northwestern University at Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project ID | NIH-11010958 on NIH RePORTER |
What this research studies
This research investigates the neural mechanisms behind working memory, focusing on how different areas of the brain contribute to this cognitive ability. Using a novel virtual reality task designed for mice, researchers will explore how specific brain circuits are activated during short-term memory tasks. The study employs advanced techniques like 2-photon microscopy and calcium imaging to observe brain activity in real-time. By identifying the roles of various cell types in the brain, the research aims to clarify how these circuits work together to support memory functions.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research would include individuals with autism spectrum disorder or related cognitive challenges.
Not a fit: Patients with cognitive impairments not related to working memory or autism spectrum disorder may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and treatment options for cognitive disorders, including autism spectrum disorder.
How similar studies have performed: Previous research has shown promising results in understanding brain circuits related to memory, indicating that this approach has potential for success.
Where this research is happening
Chicago, United States
- Northwestern University at Chicago — Chicago, United States (Active)
Researchers
- Principal investigator: Pinto, Lucas — Northwestern University at Chicago
- Study coordinator: Pinto, Lucas
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.