Understanding how brain circuits related to pain function over time
Spatiotemporal Alterations of Thalamocortical Circuitry Functioning Underlie Pain
This study is looking at how the brain processes pain to better understand what happens in both short-term and long-lasting pain, and it’s exploring a new way to help ease pain using a technique that stimulates brain activity.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11056161 on NIH RePORTER |
What this research studies
This research investigates the complex neural mechanisms underlying pain by examining how thalamocortical circuitry functions in both acute and chronic pain conditions. Using advanced neuroimaging techniques like EEG and fMRI, the study aims to identify alterations in brain connectivity and rhythms associated with pain. The researchers will also explore the potential of transcranial alternating current stimulation (tACS) to restore normal brain function and alleviate pain symptoms. By linking spatial and temporal aspects of brain activity, this research seeks to provide a more comprehensive understanding of pain management.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals suffering from chronic low back pain or other forms of chronic pain.
Not a fit: Patients with acute pain that does not persist or those without any neurological conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective interventions for managing chronic pain conditions.
How similar studies have performed: Previous research has shown promise in using neuroimaging and brain stimulation techniques to understand and treat pain, indicating that this approach may yield valuable insights.
Where this research is happening
Boston, United States
- Massachusetts General Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Kong, Jian — Massachusetts General Hospital
- Study coordinator: Kong, Jian
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.