Understanding how brain circuits involved in memory function and disease work
Activity-Dependent Plasticity in an Associative Hippocampal Circuit: Mechanisms, Synaptic Learning Rules and Involvement in Disease
This study is exploring how certain brain cells in a part of the brain important for memory work together and how changes in these cells might be linked to issues like anxiety and depression, with the hope of helping people understand their conditions better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Albert Einstein College of Medicine NIH-funded |
| Lab location | 1 site (Bronx, United States) |
| Project ID | NIH-10647661 on NIH RePORTER |
What this research studies
This research investigates the role of specific brain cells in the dentate gyrus of the hippocampus, which is crucial for memory formation. It focuses on how these cells interact and process information, particularly looking at a unique form of synaptic strengthening that does not rely on traditional mechanisms. By studying these interactions, the research aims to uncover how disruptions in this circuit may lead to various brain disorders, including anxiety and depression. Patients may benefit from insights gained into the underlying mechanisms of their conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults aged 21 and older who experience anxiety or depression.
Not a fit: Patients with conditions unrelated to memory processing or those under 21 may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for memory-related disorders and mental health conditions.
How similar studies have performed: Previous research has shown promising results in understanding synaptic mechanisms in related brain circuits, suggesting potential for success in this area.
Where this research is happening
Bronx, United States
- Albert Einstein College of Medicine — Bronx, United States (Active)
Researchers
- Principal investigator: Castillo, Pablo E — Albert Einstein College of Medicine
- Study coordinator: Castillo, Pablo E
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.