Understanding how brain circuits influence decision-making and cognition
Toward mechanistic cognitive neuroscience: cell types, connectivity, and patterned perturbations
['FUNDING_OTHER'] · HARVARD MEDICAL SCHOOL · NIH-10897282
This study is exploring how our brains make decisions and behave by looking at the connections between brain cells, using a special virtual reality setup for mice, to help us understand more about mental health issues.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | HARVARD MEDICAL SCHOOL (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-10897282 on ClinicalTrials.gov |
What this research studies
This research investigates the fundamental mechanisms of cognitive processes in the brain, particularly how they relate to decision-making and behavior. By using advanced techniques, including a virtual reality system for mice, the study aims to identify the causal links between cognitive functions and the underlying neural circuits. The researchers will analyze how different cell types and their connectivity contribute to cognitive tasks, providing insights into the biological basis of mental health disorders. This approach combines neurophysiological measurements with computational tools to better understand brain function.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing cognitive impairments related to mental health disorders, such as bipolar disorder.
Not a fit: Patients with purely physical health conditions unrelated to cognitive function may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights and treatments for mental health disorders by elucidating the biological mechanisms underlying cognitive dysfunction.
How similar studies have performed: Other research has shown success in linking neural circuit activity to cognitive processes, but this approach aims to deepen understanding in a novel way.
Where this research is happening
BOSTON, UNITED STATES
- HARVARD MEDICAL SCHOOL — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: HARVEY, CHRISTOPHER D — HARVARD MEDICAL SCHOOL
- Study coordinator: HARVEY, CHRISTOPHER D
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Bipolar Disorder