Understanding how brain cells affect reproduction
Official title: A role for hypothalamic astrocytes in neural circuits controlling reproduction
Funded at University of Michigan at Ann Arbor · NIH-11001089 · Data updated 2026-11-12
This study is looking at how certain brain cells called astrocytes help control the hormones that affect reproduction, which could help us understand fertility problems that many couples experience.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project start | January 1, 2023 |
| Project end | December 31, 2025 |
| Funding year | 2025 |
| Award (this year) | $43,136 |
| NIH project number | 5F31HD110102-03 |
| Project ID | NIH-11001089 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals experiencing infertility or reproductive issues, particularly those under 21 years old.
✕Less likely to help
Patients who are not experiencing fertility issues or are outside the age range of 21 years and older may not benefit from this research.
What this research studies
This research investigates the role of astrocytes, a type of brain cell, in regulating the neural circuits that control reproduction. By studying how these cells interact with gonadotropin-releasing hormone (GnRH) neurons, the research aims to uncover the mechanisms that influence fertility. The approach involves examining the changes in astrocyte function and their impact on hormone release during different reproductive cycles. This could provide insights into infertility issues faced by many couples.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for infertility by targeting the underlying neural mechanisms involved in reproduction.
How similar studies have gone: Previous research has shown that understanding the role of glial cells in brain function can lead to significant advancements in treating neurological disorders, suggesting potential success for this approach.
Where this research is happening
-
University of Michigan at Ann Arbor
Ann Arbor, United States Active
Researchers
- Principal investigator: Phillips, Chrystian David — University of Michigan at Ann Arbor
- Study coordinator: Phillips, Chrystian David
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.