Understanding how brain cancer grows in diffuse midline glioma
Deciphering mechanisms of transcriptional repression which drive midline glioma
This research aims to uncover how a specific type of brain cancer, diffuse midline glioma, develops so we can find new ways to treat it.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-11131035 on NIH RePORTER |
What this research studies
Diffuse midline glioma (DMG) is a very serious brain cancer affecting both children and adults, and unfortunately, current treatments are not very effective. There are currently no FDA-approved drugs specifically for DMG, highlighting a critical need for new approaches. This project focuses on a key problem in DMG where a mutated protein, called H3, improperly silences important genes that normally fight cancer. We want to understand exactly how this silencing happens, specifically looking at a complex called PRC1, to identify new targets for future medicines.
Who could benefit from this research
Good fit: This research is relevant for patients, both children and adults, diagnosed with diffuse midline glioma.
Not a fit: Patients without diffuse midline glioma would not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this research could identify new therapeutic targets, leading to the development of much-needed effective treatments for diffuse midline glioma.
How similar studies have performed: No drugs have been FDA approved for diffuse midline glioma, indicating this research explores novel and urgently needed therapeutic strategies.
Where this research is happening
Philadelphia, United States
- University of Pennsylvania — Philadelphia, United States (Active)
Researchers
- Principal investigator: Phillips, Richard E — University of Pennsylvania
- Study coordinator: Phillips, Richard E
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.