Understanding how brain cancer cells move through tight spaces
Novel Mechanisms of Confined Migration of GBM Cells
This study is looking at how glioblastoma brain cancer cells move through the brain and what makes them so good at spreading, using special tools to see how blocking certain processes affects their movement.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11075382 on NIH RePORTER |
What this research studies
This research investigates the mechanisms behind the movement of glioblastoma (GBM) cells, a highly aggressive form of brain cancer, as they navigate through the brain's narrow pathways. By using advanced techniques like microchannel devices and live-cell imaging, the study aims to uncover how certain cellular processes, such as endocytosis and changes in membrane charge, influence the ability of these cancer cells to migrate. The researchers will conduct experiments to see how inhibiting endocytosis affects the movement of GBM cells, providing insights into their invasive behavior.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with glioblastoma who are experiencing aggressive tumor growth.
Not a fit: Patients with other types of brain tumors or non-cancerous conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies that inhibit the invasive properties of GBM cells, potentially improving treatment outcomes for patients.
How similar studies have performed: Previous research has shown promise in understanding cancer cell migration, but this specific approach focusing on confined migration mechanisms is relatively novel.
Where this research is happening
New York, United States
- Icahn School of Medicine at Mount Sinai — New York, United States (Active)
Researchers
- Principal investigator: Friedel, Roland Horst — Icahn School of Medicine at Mount Sinai
- Study coordinator: Friedel, Roland Horst
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.