Understanding how brain cancer cells change over time
Decoding glioma evolution and progression by multi-dimensional single-cell profiling
This project aims to understand how brain cancer cells, specifically glioma, change and adapt to treatments, which can help us find better ways to fight the disease.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-11129612 on NIH RePORTER |
What this research studies
Brain cancer, like glioma, is challenging to treat because cancer cells can change and become resistant to therapies over time. This project uses advanced single-cell technologies to look closely at individual glioma cells, examining their genetic and epigenetic makeup. By understanding how these cells evolve and adapt, we hope to identify their weaknesses. This knowledge could lead to new treatment targets and help doctors know the best time to intervene with therapies.
Who could benefit from this research
Good fit: This foundational research is relevant for patients diagnosed with diffuse glioma, as it seeks to understand the underlying biology of their disease.
Not a fit: Patients seeking immediate new treatments or clinical trial opportunities may not directly benefit from this basic science research in the short term.
Why it matters
Potential benefit: If successful, this work could lead to new ways to identify vulnerable targets in glioma cells and improve treatment strategies for patients with this incurable brain cancer.
How similar studies have performed: While single-cell technologies are rapidly advancing, this specific approach to concurrently profile multiple aspects of glioma cells at an unprecedented detection rate is novel.
Where this research is happening
Philadelphia, United States
- University of Pennsylvania — Philadelphia, United States (Active)
Researchers
- Principal investigator: Silverbush, Dana — University of Pennsylvania
- Study coordinator: Silverbush, Dana
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.