Understanding how blood vessel types develop and function
Official title: Cell Cycle Control of Arterial-Venous Specification
Funded at University of Virginia · NIH-10993134 · Data updated 2026-11-12
This study is looking at how blood vessels grow and change during healing, focusing on how different blood flow patterns affect the cells that make up these vessels, which could help improve treatments for injuries and diseases.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Virginia NIH-funded |
| Lab location | 1 site (Charlottesville, United States) |
| Project start | December 1, 2023 |
| Project end | November 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $700,855 |
| NIH project number | 5R01HL171284-02 |
| Project ID | NIH-10993134 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions affecting blood vessel formation or repair, such as those recovering from injuries or surgeries.
✕Less likely to help
Patients with stable vascular conditions or those not requiring tissue repair may not benefit from this research.
What this research studies
This research investigates the mechanisms that control the formation and specialization of blood vessels during development and tissue repair. By studying how different types of blood flow affect the growth and behavior of endothelial cells, the research aims to identify key factors that influence whether cells develop into arteries or veins. The approach involves using advanced techniques like ATAC sequencing to analyze gene expression changes in response to varying shear stress levels. This knowledge could lead to improved strategies for tissue engineering and regenerative medicine.
Why it matters
Potential benefit: If successful, this research could enhance the development of therapies for vascular diseases and improve tissue repair processes.
How similar studies have gone: Previous studies have shown promising results in understanding blood vessel development, indicating that this research builds on established findings in the field.
Where this research is happening
-
University of Virginia
Charlottesville, United States Active
Researchers
- Principal investigator: Hirschi, Karen Kemper — University of Virginia
- Study coordinator: Hirschi, Karen Kemper
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.