Understanding how blood vessel function affects multiple organ failure in critically ill patients
Endothelial mechanisms of multiorgan dysfunction
This study is looking at how blood vessel problems in seriously ill patients in intensive care can lead to organ failure and long-term health issues, with the goal of finding new ways to help these patients recover better and avoid complications after their hospital stay.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Albany Medical College NIH-funded |
| Lab location | 1 site (Albany, United States) |
| Project ID | NIH-10770188 on NIH RePORTER |
What this research studies
This research investigates the role of blood vessel function in critically ill patients who are admitted to intensive care units. It aims to understand how severe inflammatory responses, such as those seen in sepsis, lead to organ failure and long-term health issues. By focusing on the endothelial mechanisms involved in these processes, the research seeks to identify new therapeutic strategies that could improve patient outcomes and reduce the incidence of post-intensive care syndrome (PICS). The approach includes studying the signaling pathways activated by cytokines that contribute to vascular dysfunction and organ damage.
Who could benefit from this research
Good fit: Ideal candidates for this research are critically ill patients admitted to intensive care units, particularly those experiencing severe inflammatory responses.
Not a fit: Patients who are not critically ill or those who do not require intensive care may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments that prevent long-term impairments in critically ill patients, enhancing their recovery and quality of life.
How similar studies have performed: Previous research has indicated that understanding endothelial function can lead to significant advancements in treating critically ill patients, suggesting a promising avenue for this investigation.
Where this research is happening
Albany, United States
- Albany Medical College — Albany, United States (Active)
Researchers
- Principal investigator: Adam, Alejandro Pablo — Albany Medical College
- Study coordinator: Adam, Alejandro Pablo
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.