Understanding how blood vessel function affects multiple organ failure in critically ill patients
Official title: Endothelial mechanisms of multiorgan dysfunction
Funded at Albany Medical College · NIH-10770188 · Data updated 2026-11-12
This study is looking at how blood vessel problems in seriously ill patients in intensive care can lead to organ failure and long-term health issues, with the goal of finding new ways to help these patients recover better and avoid complications after their hospital stay.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Albany Medical College NIH-funded |
| Lab location | 1 site (Albany, United States) |
| Project start | September 15, 2024 |
| Project end | August 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $409,583 |
| NIH project number | 1R35GM152454-01 |
| Project ID | NIH-10770188 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are critically ill patients admitted to intensive care units, particularly those experiencing severe inflammatory responses.
✕Less likely to help
Patients who are not critically ill or those who do not require intensive care may not benefit from this research.
What this research studies
This research investigates the role of blood vessel function in critically ill patients who are admitted to intensive care units. It aims to understand how severe inflammatory responses, such as those seen in sepsis, lead to organ failure and long-term health issues. By focusing on the endothelial mechanisms involved in these processes, the research seeks to identify new therapeutic strategies that could improve patient outcomes and reduce the incidence of post-intensive care syndrome (PICS). The approach includes studying the signaling pathways activated by cytokines that contribute to vascular dysfunction and organ damage.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments that prevent long-term impairments in critically ill patients, enhancing their recovery and quality of life.
How similar studies have gone: Previous research has indicated that understanding endothelial function can lead to significant advancements in treating critically ill patients, suggesting a promising avenue for this investigation.
Where this research is happening
-
Albany Medical College
Albany, United States Active
Researchers
- Principal investigator: Adam, Alejandro Pablo — Albany Medical College
- Study coordinator: Adam, Alejandro Pablo
Related research
Other NIH-funded projects on the same topics.
-
Endothelial inflammation memory after sepsis and pneumonia
A scientist is studying how blood vessel cells “remember” sepsis and why survivors get worse when they catch pneumonia, with the goal of finding better ways to reduce organ damage.
-
How common gut bacteria may stop C. difficile from making spores
This project looks at whether common gut bacteria called enterococci can stop C. difficile from making hardy spores that spread infection, which could help people prone to C. difficile infections.
-
Kiss1 neurons in brain regions and how they influence reproduction
A small NIH-funded project looks at how specific brain cells (Kiss1 neurons) affect reproductive hormones in adults.
-
Endothelial genes linked to Alzheimer's progression in male and female brains
Aims to find blood vessel gene targets that change as Alzheimer's progresses, in both men and women, using mouse models to mirror human disease.
-
How tumor stiffness and tissue environment affect HER2 antibody therapy
This project studies how the physical environment inside HER2-positive tumors affects how well HER2-targeting antibodies can reach and engage their target in patients.
-
KCTD11-related CMT neuropathy: uncovering how it damages nerves
We are studying a genetic form of Charcot–Marie–Tooth disease to understand what goes wrong in nerves and support future treatments.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.