Understanding how blood vessel cells function in health and disease
Molecular Mechanisms Governing Vascular Cell Function and Phenotype in Health and Disease
This study is looking at how certain cells in your blood vessels work and change when you're healthy or not, with the goal of finding new ways to help repair damaged blood vessels, which is really important for treating heart disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston Children's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10811696 on NIH RePORTER |
What this research studies
This research investigates the molecular mechanisms that affect how vascular cells, particularly endothelial cells and vascular smooth muscle cells, function and change in response to health and disease conditions. The study focuses on how these cells can be encouraged to repair damaged blood vessels, which is crucial for treating coronary heart disease. By exploring the signaling pathways and proteins involved in the transformation of vascular smooth muscle cells into endothelial cells, the research aims to identify new therapeutic strategies for improving cardiovascular health.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with cardiovascular diseases, particularly those experiencing endothelial dysfunction or atherosclerosis.
Not a fit: Patients without cardiovascular issues or those who do not exhibit endothelial dysfunction may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments that enhance the repair of damaged blood vessels, potentially reducing the risk of heart disease.
How similar studies have performed: Previous research has shown promise in similar approaches targeting vascular cell function, indicating potential for success in this area.
Where this research is happening
Boston, United States
- Boston Children's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Chen, Hong — Boston Children's Hospital
- Study coordinator: Chen, Hong
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.