Understanding how blood flow affects artery health
Epigenetic regulation of vascular endothelial genes and laminar flow atheroprotection
This study is looking at how different blood flow patterns affect artery health, especially for people with atherosclerosis, and aims to find ways to protect arteries from damage so that new treatments can be developed to help keep them healthy.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project ID | NIH-10430272 on NIH RePORTER |
What this research studies
This research investigates how different types of blood flow impact the health of arteries, particularly focusing on atherosclerosis, a leading cause of death. The team aims to identify specific signaling molecules that protect arteries from damage caused by disturbed blood flow. By understanding these protective mechanisms, they hope to develop new treatments that can mimic this protection in vulnerable areas of the arteries. The research employs advanced techniques to explore epigenetic changes in endothelial cells in response to varying blood flow conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at risk for atherosclerosis, including those with cardiovascular disease or related risk factors.
Not a fit: Patients with established atherosclerosis or those who do not have risk factors for cardiovascular disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that prevent or reduce the risk of atherosclerosis in patients.
How similar studies have performed: Previous research has shown promising results in understanding the mechanisms of atherosclerosis, suggesting that this approach could yield significant insights.
Where this research is happening
Rochester, United States
- University of Rochester — Rochester, United States (Active)
Researchers
- Principal investigator: Jin, Zheng-Gen — University of Rochester
- Study coordinator: Jin, Zheng-Gen
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.