Understanding how blood fats affect blood vessel health
Official title: Blood TG clearance and vascular biology
Funded at NYU Long Island School of Medicine · NIH-11064061 · Data updated 2026-11-12
This study is looking at how certain fats in your blood affect the cells that line your blood vessels, which could help us understand how heart disease develops, and it's designed for anyone interested in heart health.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | NYU Long Island School of Medicine NIH-funded |
| Lab location | 1 site (Mineola, United States) |
| Project start | May 1, 2023 |
| Project end | April 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $566,758 |
| NIH project number | 5P01HL160470-03 |
| Project ID | NIH-11064061 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals at risk for atherosclerosis, including those with high triglyceride levels or other cardiovascular risk factors.
✕Less likely to help
Patients who do not have cardiovascular risk factors or existing atherosclerotic disease may not benefit from this research.
What this research studies
This research investigates the processes by which certain fats in the blood, particularly triglyceride-rich lipoproteins, interact with cells lining blood vessels. It focuses on how these fats are taken up by endothelial cells and how this uptake may contribute to the development of atherosclerosis, a condition that can lead to heart disease. The study employs advanced techniques using genetically modified mice to explore the mechanisms of fat processing and its implications for vascular health. By understanding these processes, the research aims to uncover potential targets for preventing or treating cardiovascular diseases.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating atherosclerosis and related cardiovascular diseases.
How similar studies have gone: Previous research has shown that understanding lipid interactions with endothelial cells can lead to significant advancements in cardiovascular disease treatment, indicating that this approach has potential for success.
Where this research is happening
-
NYU Long Island School of Medicine
Mineola, United States Active
Researchers
- Principal investigator: Goldberg, Ira J — NYU Long Island School of Medicine
- Study coordinator: Goldberg, Ira J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.