Understanding how blood clotting mechanisms affect severe COVID-19 outcomes
Mechanisms linking the plasminogen/fibrinogen axis to the pathogenesis of COVID-19
This study is looking at how certain blood factors might affect the severity of COVID-19 symptoms, especially why some people get really sick while others don’t, by checking blood and tissue samples from patients to find clues that could help improve treatment for those with severe illness.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of North Carolina Chapel Hill NIH-funded |
| Lab location | 1 site (Chapel Hill, United States) |
| Project ID | NIH-10901935 on NIH RePORTER |
What this research studies
This research investigates the role of the plasminogen/fibrinogen axis in the development of severe COVID-19 symptoms, particularly focusing on how blood clotting and inflammation contribute to acute respiratory distress syndrome (ARDS). By examining the molecular mechanisms behind fibrin deposits in patients' lungs and other organs, the study aims to uncover why some individuals experience severe disease while others have mild symptoms. The approach includes analyzing blood samples and tissue from COVID-19 patients to identify biomarkers that correlate with disease severity. This could lead to better understanding and management of COVID-19 complications.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with COVID-19 who are experiencing severe symptoms or complications, particularly those with ARDS.
Not a fit: Patients with mild or asymptomatic COVID-19 infections may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies for patients suffering from severe COVID-19 and related complications.
How similar studies have performed: Previous research has indicated that understanding blood coagulation mechanisms can significantly impact treatment outcomes in severe respiratory infections, suggesting potential for success in this area.
Where this research is happening
Chapel Hill, United States
- Univ of North Carolina Chapel Hill — Chapel Hill, United States (Active)
Researchers
- Principal investigator: Flick, Matthew J. — Univ of North Carolina Chapel Hill
- Study coordinator: Flick, Matthew J.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.