Understanding how blood cells interact to affect heart health in people with HIV
Role of platelet- monocyte interaction in promoting pro-atherogenic state in HIV-infected individuals
This research looks at how certain blood cells, called platelets and monocytes, interact to affect heart and blood vessel health in people living with HIV.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project ID | NIH-11117034 on NIH RePORTER |
What this research studies
We know that people with HIV often face a higher risk of heart and blood vessel problems, partly because of ongoing inflammation. This project explores how two types of blood cells, platelets and monocytes, work together to contribute to this risk. We believe that when these cells interact, they form complexes that can trigger changes in monocytes, making them more likely to promote hardening of the arteries. By understanding how these cells communicate and transfer materials, we hope to uncover new ways to protect heart health in people with HIV.
Who could benefit from this research
Good fit: This research is relevant for individuals living with HIV who are at risk for or experiencing cardiovascular disease.
Not a fit: Patients without HIV or those not at risk for cardiovascular complications related to HIV may not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to new ways to prevent or treat heart and blood vessel disease in people living with HIV.
How similar studies have performed: Previous studies have shown that platelet-monocyte complexes are increased in HIV infection and cardiovascular disease, suggesting this approach builds on existing observations.
Where this research is happening
Rochester, United States
- University of Rochester — Rochester, United States (Active)
Researchers
- Principal investigator: Thakar, Juilee — University of Rochester
- Study coordinator: Thakar, Juilee
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.