Understanding how blood cells contribute to heart disease
PROJECT 1: Modulating blood cell heterogeneity to reduce cardiovascular inflammation
['FUNDING_P01'] · MASSACHUSETTS GENERAL HOSPITAL · NIH-11012929
This study is looking at how specific blood cells, shaped by our genes, can affect heart disease, and it hopes to find ways to change how these cells work to help reduce inflammation and slow down heart problems, which could lead to better treatments for patients like you.
Quick facts
| Phase | ['FUNDING_P01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | MASSACHUSETTS GENERAL HOSPITAL (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-11012929 on ClinicalTrials.gov |
What this research studies
This research investigates how certain blood cell clones, influenced by their genetic makeup, contribute to the development of cardiovascular disease. By examining how these cells behave in different conditions, the study aims to identify ways to modify their functions to reduce inflammation and slow down heart disease progression. Patients may benefit from insights into how their own blood cells could be targeted for more effective treatments. The research employs advanced techniques to analyze blood and bone marrow cells in various atherogenic states.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals at risk for or currently experiencing cardiovascular disease.
Not a fit: Patients with non-cardiovascular related conditions or those without any cardiovascular risk factors may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating cardiovascular disease by targeting specific blood cell behaviors.
How similar studies have performed: Previous research has shown promising results in modifying blood cell functions to impact cardiovascular health, suggesting that this approach could be effective.
Where this research is happening
BOSTON, UNITED STATES
- MASSACHUSETTS GENERAL HOSPITAL — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SCADDEN, DAVID T — MASSACHUSETTS GENERAL HOSPITAL
- Study coordinator: SCADDEN, DAVID T
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Atherosclerotic Cardiovascular Disease, atherosclerotic disease, atherosclerotic vascular disease