Understanding how blood cell changes relate to heart disease
PROJECT 4: Somatic evolution of the hematopoietic system in cardiovascular disease
This study is looking at how changes in your blood cells might be linked to heart disease, helping us understand if these changes can affect your heart health and potentially lead to new treatments.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11012932 on NIH RePORTER |
What this research studies
This research investigates the connection between cardiovascular disease (CVD) and changes in blood cell populations known as clonal hematopoiesis (CH). It aims to clarify how these blood cell changes, which may carry mutations, contribute to the progression of heart disease. The researchers will develop advanced techniques to detect these changes in blood samples, allowing for a better understanding of their role in CVD. By identifying the relationship between CVD and both mutated and non-mutated blood cells, the study seeks to inform new therapeutic approaches.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with cardiovascular disease who may also have changes in their blood cell populations.
Not a fit: Patients without cardiovascular disease or those who do not exhibit clonal hematopoiesis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostic and therapeutic strategies for patients with cardiovascular disease.
How similar studies have performed: Previous research has shown promising results in understanding the links between blood cell mutations and cardiovascular conditions, suggesting that this approach could yield valuable insights.
Where this research is happening
Boston, United States
- Massachusetts General Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Naxerova, Kamila — Massachusetts General Hospital
- Study coordinator: Naxerova, Kamila
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.